Madrigal is a biopharmaceutical company pursuing novel therapeutics for non-alcoholic steatohepatitis (NASH), also known as metabolic dysfunction associated steatohepatitis (MASH). Our first therapy, Rezdiffra (resmetirom), was granted accelerated approval by the U.S. Food and Drug Administration (FDA) for the treatment of adults with NASH with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis) and is being studied in a Phase 3 trial for the treatment of NASH with compensated cirrhosis.
Title: Sr. Director, Clinical Practice Liaison (CPL)
Role Summary
The Sr. Director, Clinical Practice Liaison (CPL) is a key field-based leadership position responsible for the strategic and tactical oversight of the CPL team within a defined U.S. region. This individual will play a critical role in managing and developing CPLs, ensuring the team executes against the company’s medical strategy, complies with regulatory and internal policies, and delivers scientific value to both internal and external stakeholders.
This position will interface regularly and compliantly with cross-functional colleagues (e.g., Marketing, Sales, Market Access, Clinical Operations, HQ Medical Affairs) and external partners, including Thought Leaders (TL), healthcare decision-makers, and other relevant stakeholders.
Key Responsibilities
Team Leadership & Development
Recruit, coach, and manage performance of regional CPLs
Foster continuous development through mentoring and training
Align CPL activities with strategic objectives and tactical plans
Medical Strategy Execution
Drive implementation of regional field medical strategies
Translate national objectives into actionable, regionally tailored activities
Partner with cross-functional teams to integrate field insights into medical planning
Cross-functional Collaboration
Collaborate closely with Sales, Marketing, Market Access, and Clinical Operations
Serve as a field-based liaison for HQ Medical Affairs initiatives
Contribute to launch readiness and lifecycle management strategies
Clinical Trial Support
Collaborate with Clinical Operations to ensure successful study execution based upon recognized needs
Congress & External Engagement
Represent Medical Affairs at U.S. medical congresses in a compliant manner
Coordinate booth planning, scientific exchange, competitive intelligence, and post-conference debriefs
Strategic Team Building
Contribute to the design and structure of the U.S. Field Medical team
Identify evolving business needs and adjust regional capabilities accordingly
Compliance & Quality
Ensure all CPL activities comply with company SOPs, industry standards, and applicable regulations
Uphold the highest ethical standards in all external engagements
Travel Requirement
Willingness to travel 25–75% for congresses, site visits, and stakeholder engagement
Qualifications & Experience
Advanced degree in a scientific or healthcare discipline (MD, PharmD, PhD, DNP, etc.)
Minimum 5 years of Medical Affairs experience, including at least 3 years as an MSL or equivalent (translatable clinical practice experience will be considered)
Minimum 3 years of people management experience or formal leadership development participation
In-depth knowledge of clinical medicine and medical research; experience in cardiometabolic health, or MASH/NASH preferred
Proven ability to understand, communicate, and translate complex scientific information
Strong knowledge of U.S. healthcare system, FDA regulations, and medical affairs compliance standards
Demonstrated cross-functional collaboration, project execution, and strategic planning skills
Proficiency in Microsoft Office Suite, virtual communication platforms (e.g., Zoom), and CRM systems (e.g., Veeva)
Preferred Attributes
Strong interpersonal, presentation, and relationship-building skills
Adaptable and proactive in a fast-paced, evolving environment
Passion for mentoring, team building, and field-based medical innovation
Compensation: Base salary is determined by several factors that include, but are not limited to, a successful candidate's qualifications, skills, education, experience, business needs, and market demands. The role may also be eligible for bonus, equity, and comprehensive benefits, which include flexible paid time off (PTO), medical, dental, vision, and life and disability insurance.
Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.
Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.
Please be aware that we are currently receiving numerous reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. Interviews with Madrigal are conducted via the Zoom platform.
Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for Madrigal we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks.