Wave Life Sciences

Title: Senior Director/Executive Medical Director, Global Clinical Lead

Location: Lexington, MA

Specialties: Cardiology, Metabolism

Summary

Leads global clinical research initiatives and registration activities for Cardio Metabolism programs, designing and overseeing clinical trials and programs. Responsible for clinical development strategy, program oversight, and execution of multiple early-stage assets. Manages cross-functional collaborations, regulatory and vendor-related issues, and influences senior leadership with innovative solutions.

Added on: 08/14/2025

Full Job Description

Job Description

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline includes clinical programs in Duchenne muscular dystrophy, Alpha-1 antitrypsin deficiency and Huntington’s disease, as well as a clinical program in obesity and a preclinical program in NASH/MASH. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

Description

Reporting to the Head of Clinical Development, the Global Clinical Lead works closely with our Cardio Metabolism program teams. In this role, you will operate independently, leveraging extensive expertise and in-depth knowledge of clinical research to design, oversee, and deliver the results of clinical trials and programs. This role entails leading global clinical research initiatives and registration activities across one or more clinical programs. As a key leadership position, the global clinical lead serves as the single point of accountability for clinical development strategy, program oversight, and the execution of multiple early-stage assets.

Experience

12+ years of industry experience in drug development including experience in early and late phase drug development and regulatory knowledge M.D. with a focus in Cardio Metabolism Proven experience overseeing early-stage Cardio Metabolism programs at a biotechnology company

Responsibilities

Has comprehensive knowledge of organizational, regulatory, and vendor-related issues, allowing them to propose improvements for products, processes, and services Leads complex, high risk global strategic programs or projects and is capable of developing the strategy for successful execution Addresses unique and strategic challenges with significant impact on Wave's clinical development, requiring innovative and conceptual thinking to create effective solutions Proven ability to effectively communicate complex ideas, anticipate potential objections, and influence senior leaders to consider and adopt alternative perspectives Develops strategic and cohesive clinical development plans that align with business objectives Lead the overall development of project strategy and be accountable for project plans, timelines, progress, and outcomes Proven success in fostering and leading cross-functional collaborations both internally and externally Demonstrated organizational and project management skills Foster strong working relationships with opinion leaders in the field

Key Skills

Strong track record of overseeing patient care and data integrity to develop safe, effective treatments Ability to manage clinical development teams, design and deliver clinical trials, and ensure the quality and timeliness of projects Experience working in a global cross-functional team environment Strong interpersonal skills; a team player Technical expertise in Microsoft Word, PowerPoint, and Excel

Wave Life Sciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Wave Life Sciences complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Wave Life Sciences expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status. Improper interference with the ability of Wave Life Sciences’ employees to perform their job duties may result in discipline up to and including discharge.

We value our relationships with professional recruitment firms. To protect the interests of all parties, and given the large volume of inquiries received from third-party placement agencies, we are not able to respond to all agency inquiries. We do not accept unsolicited resumes from any source other than directly from candidates for current or future positions. Submission of unsolicited resumes in advance of a signed agreement between our company and a placement agency does not create an implied obligation and, if an unsolicited candidate represented by a placement agency is hired, we are not obligated to pay a fee. Only approved recruitment firms will be allowed to provide services to Wave Life Sciences, USA.