Baylor College of Medicine
Pediatrics - Neurology (Instructor)
The Instructor will support and lead translational neuroscience research focused on the molecular and cellular mechanisms underlying neurodevelopmental disorders, with an emphasis on cerebellar development and EBF3-associated disorders. The role involves contributing to NIH-funded projects using mouse models, hiPSC systems, single-cell genomics, and molecular biology approaches, while independently managing research activities, supervising trainees and staff, and assisting with manuscript and grant preparation.
Key Responsibilities
- • Design and conduct independent and collaborative research studies related to cerebellar neurodevelopment and neurodevelopmental disorders.
- • Perform and oversee molecular, cellular, and developmental neuroscience experiments including:
- • hiPSC culture and neuronal differentiation
- • Mouse colony management and transgenic breeding strategies
- • Immunohistochemistry and immunofluorescence
- • Single-cell RNA sequencing analyses
- • CUT&RUN sequencing and ChIP-qPCR
- • Flow cytometry and cell sorting
- • CRISPR gene editing methodologies
- • DNA/RNA/protein extraction and downstream analyses
- • Analyze and interpret experimental data using statistical and bioinformatics approaches.
- • Develop and optimize protocols for genomic and functional assays.
- • Coordinate research activities across laboratory personnel and collaborating investigators.
- • Prepare figures, manuscripts, abstracts, presentations, and progress reports for publications and sponsored projects.
- • Assist Principal Investigator with grant submissions, regulatory documentation, and scientific reporting requirements.
- • Train and mentor graduate students, research staff, and trainees in laboratory procedures and experimental design.
- • Maintain compliance with institutional, federal, and sponsor regulations related to animal and human subject research.
- • Participate in departmental seminars, scientific meetings, and collaborative research initiatives.
Required
- • PhD, MD, or equivalent doctoral degree in Neuroscience, Molecular Biology, Genetics, Developmental Biology, or related scientific field.
- • Minimum of 2–4 years of postdoctoral or advanced research experience in neurodevelopmental biology, molecular genetics, or related discipline.
- • Demonstrated experience with molecular biology, mouse models, cell culture, and genomic techniques.
- • Strong written and verbal communication skills.
- • Record of peer-reviewed publications.
Summary
The Instructor will support and lead translational neuroscience research focused on the molecular and cellular mechanisms underlying neurodevelopmental disorders (NDDs), with an emphasis on cerebellar development and EBF3-associated disorders. The individual will contribute to NIH-funded projects involving mouse models, human induced pluripotent stem cell (hiPSC) systems, single-cell genomics, and molecular biology approaches to investigate lineage-specific developmental processes and gene regulatory networks.
The Instructor is expected to independently manage research activities, contribute to experimental design and data interpretation, supervise trainees and staff, and assist with manuscript and grant preparation.
Job Duties
The Instructor will support and lead translational neuroscience research focused on the molecular and cellular mechanisms underlying neurodevelopmental disorders (NDDs), with an emphasis on cerebellar development and EBF3-associated disorders. The individual will contribute to NIH-funded projects involving mouse models, human induced pluripotent stem cell (hiPSC) systems, single-cell genomics, and molecular biology approaches to investigate lineage-specific developmental processes and gene regulatory networks.
The Instructor is expected to independently manage research activities, contribute to experimental design and data interpretation, supervise trainees and staff, and assist with manuscript and grant preparation.
Job Duties
- Design and conduct independent and collaborative research studies related to cerebellar neurodevelopment and neurodevelopmental disorders.
- Perform and oversee molecular, cellular, and developmental neuroscience experiments including:
- hiPSC culture and neuronal differentiation
- Mouse colony management and transgenic breeding strategies
- Immunohistochemistry and immunofluorescence
- Single-cell RNA sequencing analyses
- CUT&RUN sequencing and ChIP-qPCR
- Flow cytometry and cell sorting
- CRISPR gene editing methodologies
- DNA/RNA/protein extraction and downstream analyses
- Analyze and interpret experimental data using statistical and bioinformatics approaches.
- Develop and optimize protocols for genomic and functional assays.
- Coordinate research activities across laboratory personnel and collaborating investigators.
- Prepare figures, manuscripts, abstracts, presentations, and progress reports for publications and sponsored projects.
- Assist Principal Investigator with grant submissions, regulatory documentation, and scientific reporting requirements.
- Train and mentor graduate students, research staff, and trainees in laboratory procedures and experimental design.
- Maintain compliance with institutional, federal, and sponsor regulations related to animal and human subject research.
- Participate in departmental seminars, scientific meetings, and collaborative research initiatives.
- PhD, MD, or equivalent doctoral degree in Neuroscience, Molecular Biology, Genetics, Developmental Biology, or related scientific field.
- Minimum of 2–4 years of postdoctoral or advanced research experience in neurodevelopmental biology, molecular genetics, or related discipline.
- Demonstrated experience with molecular biology, mouse models, cell culture, and genomic techniques.
- Strong written and verbal communication skills.
- Record of peer-reviewed publications.
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