Karyopharm Therapeutics Inc.

The Medical Science Liaison (MSL), Hematology serves as Karyopharm’s field-based scientific expert supporting multiple myeloma and emerging hematology programs, including potential future indications in myelofibrosis. The MSL is responsible for developing and maintaining strategic relationships with national, regional, and community-based thought leaders, investigators, healthcare professionals, and health systems. This role facilitates the compliant exchange of scientific information, gathers actionable medical insights, supports evidence generation activities, and helps advance Karyopharm’s hematology strategy.

We are seeking MSLs across multiple U.S. territories. Candidates should indicate their preferred geography when applying.

Responsibilities

• Develop scientific relationships with hematology thought leaders, investigators, and treatment centers focused on multiple myeloma and related hematologic malignancies.
• Serve as Karyopharm’s scientific representative and facilitate balanced, compliant scientific exchange.
• Gather and communicate medical insights, treatment trends, competitive intelligence, and unmet needs.
• Support clinical trial awareness, site identification, and investigator engagement activities in partnership with Clinical Development.
• Support investigator-sponsored research and scientific collaboration opportunities.
• Participate in advisory boards, congresses, steering committees, and medical education initiatives.
• Partner closely with Medical Affairs, Clinical Development, Commercial, Market Access, and HEOR teams. Mentor less experienced MSLs and contribute to special projects as assigned.
  
  

Qualifications

Candidate Profile & Requirements:

• Advanced doctoral degree preferred (PharmD, MD, DO, PhD); candidates with advanced clinical degrees and significant oncology MSL experience will be considered.
• 3+ years of oncology MSL experience required.
• Experience in multiple myeloma required; myelofibrosis experience preferred.
• Product launch and pre-launch experience preferred.
• Strong scientific communication and presentation skills.
• Demonstrated ability to build relationships with hematology thought leaders.
• Ability to travel up to 75%.
  
  

At Karyopharm, base pay is one part of a competitive total rewards package that includes comprehensive benefits (medical, dental, vision, 401(k), and more), equity and the potential to receive annual target bonuses. Actual pay is based on factors such as location, experience, skills, education, and internal equity. We maintain broad salary ranges to reflect market conditions and the specialized nature of our work. The anticipated base salary range for this position is $180 K - $220 K USD.

Our Value Proposition

This is a uniquely exciting time to join Karyopharm Therapeutics where we are pioneering the science of nuclear export inhibition to develop differentiated therapies for patients with cancer. We are building upon an established commercial foundation in multiple myeloma while advancing the potential of selinexor across additional hematologic and solid tumor cancers including myelofibrosis and TP53 wild-type endometrial cancer, areas where patients continue to face significant unmet needs.

Our lead therapy, XPOVIO ® (selinexor), is a first-in-class inhibitor of exportin 1 (XPO1) and is approved in the U.S. for adults with relapsed or refractory multiple myeloma, with approvals in more than 50 countries and territories outside the U.S. We are also exploring opportunities to evaluate XPO1 inhibition across myeloproliferative neoplasms and TP53 wild-type driven solid tumors using next-generation compounds, including eltanexor.

As we prepare for our next phase of growth, we are continuing to invest in critical capabilities across the organization to support future opportunities and deepen our impact in oncology. We are looking for talented people who are motivated by meaningful work, energized by growth and momentum, and excited by the opportunity to help shape what comes next in a collaborative, fast-moving environment where individual contributions are visible and valued.

Learn more at Karyopharm Therapeutics .